PENGARUH PEMBERIAN EKSTRAK KULIT PISANG KEPOK KUNING (Musa balbisiana) TERHADAP ASUPAN MAKAN DAN BERAT BADAN TIKUS WISTAR (Rattus norvegicus) JANTAN

Wiwiek Fatchurohmah, Andreanyta Meliala


Abstract


A positive energy imbalance results in overweight and obesity. Overweight and obesity are the major risk factors for many diseases, including diabetes, cardiovascular diseases, and mental health. Animal studies suggested that serotonin involves in food intake control. The Banana peel is a potential natural source of serotonin precursor; furthermore, it may influence food intake. This study aimed to determine the effect of banana peel extract on food intake and body weight gain in male Wistar rats. Twenty-four male Wistar rats (8-10 weeks old), were divided into four groups for feeding treatment. All four group were; the control group (C), the banana peel extract dosage of 4 g/kg BW group (T1), the banana peel extract dosage of 8 g/kg BW (T2), and the banana peel extract dosage of 16 g/kg BW (T3). The food intakes were measured daily, while rats body weights were recorded at the beginning and the end of the three days experimental periods. The study found the rats in the T1 group (8.80 ± 2.63) showed no significant difference in food intake compared to C group (10.68 ± 1.89), T2 group (6.65 ± 3.12), and T3 group (5.42 ± 1.59). Rats in the T2 group (p = 0.038) and T3 group (p = 0.005) showed lower food intake significantly compared to control group. After three days of treatment, the T3 group showed a significant decrease in body weight compared to control group (p = 0.008). This study concluded, the administration of banana peel extract dosage of 8 g/kg BW and 16 g/kg BW suppressed food intake, while the dosage of 16 g/kg BW reduced the body weight in male Wistar rats.


Keywords


food intake; banana peel; Wistar rat

References


Amer A, Breu J, McDermott J, Wurtman RJ, Maher TJ. 2004. 5-Hydroxy-L-tryptophan suppresses food intake in food deprived and stressed rats. Pharmacology, Biochemistry and Behavior 77:137–143 https://doi.org/10.1016/j.pbb.2003.10.011

Arase K, Sakaguchi T, Bray GA. 1988. Effect of fenfluramine on sympathetic firing rate. Pharmacology, Biochemestry and Behavior 29: 675-680. https://doi.org/10.1016/0091-3057(88)90186-4

Baumann MH, Williams Z, Zolkowska D, Rothman RB. 2011. Serotonin precursor loading with 5-HTP reduces locomotor activation produced by (+)-amphetamine in the rat. Drug and Alcohol 114:147-152

Birdsall TC. 1998. 5-Hydroxytryptophan: A clinally–effective serotonin precursor. Alternative medicine Review 3(4):271-278

Ceci F, Cangiano C, Cairella M, Cascino A, Del Ben M, Muscaritoli M, Sibilia L, Fanelli FR. 1988. The effects of oral 5-HTP administration on feeding behavior in obese adult female subjects. Journal of neural Transmission 76:109-117 https://doi.org/10.1007/BF01578751

Coskun S, Ozer C, Gonul B, Take G, Erdogan D. 2005. Effect of repeated tryptophan administration on body wight, food intake, brain lipid peroxidation and serotonin immunoreactivity in mice. Molecular and Cellular Biochemistry 286:133–138 https://doi.org/10.1007/s11010-005-9103-5

Emaga TH, Andrianaivo RH, Wathelet B, Tchango J T, Paquot M., 2007. Effects of the stage of maturation and varieties on the chemical composition of banana and plantain peels. Food Chemistry 103:590-600. https://doi.org/10.1016/j.foodchem.2006.09.006

Feijo FdM, Bertoluci MC, Reis M. 2011. Serotonin and hypothalamic control of hunger: a review. Revista da Associação Médica Brasileira (English Edition) 57:74-77 https://doi.org/10.1016/S0104-4230(11)70020-3

Gao Q, Horvath TL. 2008. Neuronal control of energy homeostasis. FEBS Letters 582: 132–141 https://doi.org/10.1016/j.febslet.2007.11.063

Gershon MD, Tack J. 2007. The serotonin signalling system: From basic understanding to drug development for functional gastrointestinal disorders. Gastroenterology 132:397-414 https://doi.org/10.1053/j.gastro.2006.11.002

Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H. 2002. Activation of central melanocortin pathways by fenfluramine. Science 297: 609-611. https://doi.org/10.1126/science.1072327

Hranilovick D, Blazevic S, Ivica N, Cicin-Sain L, Oreskovic D. 2011. The Effects of the perinatal treatment with 5-hydroxytryptophan or tranylicypromine on the peripheral and central serotonin homeostasis in adult rats. Neurochemistry International 59:202-207 https://doi.org/10.1016/j.neuint.2011.05.003

Kema IP, Schellings AMJ, Melborg G, Hoppenbrouwers CJM, Muskiet FAJ. 1992. Influence of a Serotonin- and Dopamine-Rich Diet on Platelet Serotonin Content and Urinary Excretion of Biogenic Amines and Their Metabolites. Clinical Chemistry 38 (9):1730-1736

Kim DY, Camilleri M. 2000. Serotonin: A mediator of the brain-gut connection. The American Journal of Gastroenterology 95:2698-2708

Lam DD, Garfield AS, Marston OJ, Shaw J, Heisler LK. 2010. Brain serotonin system in the coordination of food intake and body weight. Pharmacology, Biochemestry and Behavior 97:84-91. https://doi.org/10.1016/j.pbb.2010.09.003

Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG. 2010. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Archives of General Psychiatry 67(3):220-9 https://doi.org/10.1001/archgenpsychiatry.2010.2

Lyn-Bullock CP, Weishans K, Pallas SL, Katz PS. 2004. The Effect of oral 5-HTP administration on 5-HTP and 5-HT immunoreactivity in monoaminergic brain regions of rats. Journal of Chemical Neuroanatomy 27:129-138 https://doi.org/10.1016/j.jchemneu.2004.02.003

Moshfegh A, Joseph G, Jaspreet A, Donna R, Randy LC. 2009. What We Eat in America. NHANES 2005-2006: Usual Nutrient Intakes from Food and Water Compared to 1997 Dietary Reference Intakes for Vitamin D, Calcium, Phosphorus, and Magnesium. U.S. Department of Agriculture, Agricultural Research Service.

Musumeci G, Loreto C, Trovato FM, Giunta S, Imbesi R, Castrogiovanni P. 2014. Serotonin expression in rat pups treated with hightryptophan diet during fetal and early postnatal development. Acta Histochemica 116:335-343 https://doi.org/10.1016/j.acthis.2013.08.011

Namkung J, Kim H, Park S. 2015. Peripheral Serotonin: a New Player in Systemic Energy Homeostasis. Molecular and Cellular 38 (12):1023 1028 https://doi.org/10.14348/molcells.2015.0258

Ohla S, Schulze P, Fritzsche S. 2011. Chip electrophoresis of active banana ingredients with label-free detection utilizing deep UV native fluorescence and mass spectrophotometry. Analytical and Bioanalytical Chemistry 399:1853-1857 https://doi.org/10.1007/s00216-010-4557-z

Ortega FB, Lavie CJ, Blair SN.2016. Obesity and cardiovascular disease. Circulation Research 118(11):1752-1770 https://doi.org/10.1161/CIRCRESAHA.115.306883

Ramakrishna A, Giridhar P, Ravishankar GA. 2011. Phytoserotonin. Plant Signaling & Behavior 6(6):800-809 https://doi.org/10.4161/psb.6.6.15242

Rothwell NJ, Stock MJ. 1987. Effect of diet and fenfluramine on thermogenesis in the rat: possible involvement of serotonergic mechanisms. International Journal of Obesity 11: 319-324.

Sakaguchi T, Bray GA. 1989. Effect of norepinephrine, serotonin and tryptophan on the firing rate of sympathetic nerves. Brain Research. 492:271-280. https://doi.org/10.1016/0006-8993(89)90910-4

Sarwar G. 2001. Influence of tryptophan supplementation of soy-based infant formulas on protein quality and on blood and brain tryptophan and brain serotonin in the rat model. Plant Foods Human Nutrition 56 (3):275-284 https://doi.org/10.1023/A:1011121111899

Sohn JW, Elmquist JK, Williams KW. 2013. Neuronal circuits that regulate feeding behavior and metabolism. Trends of Neuroscience. 36:504-512. https://doi.org/10.1016/j.tins.2013.05.003

Szewczyk B, Poleszak E, Sowa-Kućma M, Siwek M, Dudek D, Ryswezka-Pokrasniewicz B, Opoka W, Csekaj J, Nowak G. 2008. Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action. Pharmacology Reports 60(5):588-589

Tee TP, Hassan H. 2011. Antidepressant-Like Activity of Banana Peel Extract in Mice. American Medical Journal 2 (2): 59-64 https://doi.org/10.3844/amjsp.2011.59.64

Wurtman RJ, Wurtman JJ, Regan MM, McDermott JM, Tsay RH, Breu, JJ. 2003. Effects of normal meals rich in carbohydrates or proteins on plasma tryptophan and tyrosine ratios. American Journal of Clinical Nutrition 77(1):128-32.


Article Reads

Total: 142 Abstract: 70 PDF (Bahasa Indonesia): 72

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

 

This website is maintained by:
The Faculty of Biology Publishing 
Universitas Jenderal Soedirman
Jalan dr. Suparno 63 Grendeng
Purwokerto 53122

Telephone: +62-281-625865
Email: biologi@unsoed.ac.id

This website uses: 
OJS | Open Journal System
A free journal management and publishing system that has been developed by the PKP (Public Knowledge Project) version 2.4.8.0.

All article content metadata are registered to:
Crossref
An official non profit Registration Agency of the International Digital Object Identifier (DOI) Foundation.

Artikel jurnal ini terindeks:

Complete index list »